Medications That Cause Sun Sensitivity: What You Need to Know
Some medications can make your skin more sensitive to sunlight, increasing the risk of sunburn, rashes, and other skin reactions. This condition is known as photosensitivity, and it can occur when your body reacts to UV radiation—specifically UVA and UVB rays—while taking certain drugs.
Whether you’re treating a chronic skin condition or managing other health concerns, it’s important to understand how your medications may affect your sun sensitivity and how to protect yourself from unwanted side effects.
What Is Drug-Induced Photosensitivity?
Drug-induced photosensitivity is a reaction that occurs when certain medications make your skin more vulnerable to the sun. For some, this means a faster or more severe sunburn than usual. For others, it may cause redness, itching, or blistering—even with minimal sun exposure.
While not everyone will experience these side effects, people with HIV or compromised immune systems are more likely to develop phototoxic reactions.
Why It Matters for People With Skin Conditions
If you have a skin condition like eczema, psoriasis, or vitiligo, photosensitive reactions from medications can trigger flare-ups or worsen symptoms. UV-related side effects—such as sunburn or erythema (redness of the skin)—can further irritate already sensitive skin, delay healing, and reduce treatment effectiveness.
Common Medications That Increase Sun Sensitivity
Several medications are known to cause photosensitivity or phototoxicity. These include:
- Certain antibiotics (like tetracyclines and fluoroquinolones)
- NSAIDs (nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen)
- Diuretics
- Some antifungals
- Retinoids used for acne treatment
- Antihistamines
- Chemotherapy drugs
- Psoralens (used in PUVA phototherapy)
💡 Psoralens are a special class of drugs that increase UVA absorption. When used intentionally in combination with UVA light (a treatment called PUVA therapy), they can provide powerful relief for certain conditions like psoriasis—but only under medical supervision.
How to Protect Yourself From Sun Sensitivity
If you’re taking a medication that increases sun sensitivity, follow these steps to stay safe:
- Use a broad-spectrum sunscreen with SPF 30 or higher
- Avoid direct sunlight between 10 AM and 4 PM
- Wear protective clothing, hats, and sunglasses
- Check ingredient labels on skincare and medications
- Consult your doctor before beginning phototherapy or spending extended time in the sun
Talk to Your Healthcare Provider
If you’re starting a new medication—or if you notice unusual skin reactions during sun exposure—talk to your healthcare provider. They can help determine whether your treatment plan needs adjusting or if extra sun protection is needed.
Being aware of the medications that increase sun sensitivity is an important part of managing your overall skin health.
References
Drucker AM, Rosen CF. Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf. 2011 Oct 1;34(10):821-37.
Gange RW, Parrish JA. Cutaneous phototoxicity due to psoralens. Natl Cancer Inst. Monogr. 1984 Dec;66:117-26.